Senior Director, Program Management

Company: Dyne Therapeutics
Location: Waltham
Posted on: March 19, 2026

Job Description:

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/ , and follow us on X , LinkedIn and Facebook . Role Summary: The Senior Director, Program Management (PM) is a critical role within the cross-functional development team responsible for facilitating and driving execution across the wide spectrum of activities required for successful development of one or more molecules. The PM partners closely with the Program Team Leader (PTL) and functional subject matter experts to ensure that plans are in place with appropriate detail and risk awareness to assure successful achievement of the goals of the development team. The PM ensures integration of these detailed functional plans into a holistic, cohesive, and comprehensive program plan that achieves the strategic goals of the development program. Given the inherent uncertainty associated with drug development in rare disorders, the PM maintains an agile mindset in order to effectively incorporate and react to emerging data and course correct as conditions dictate. Working in close partnership with the PTL, the PM effectively frames and facilitates discussions with team members and external experts to elicit clear recommendations and decisions by fully engaging with team members to consider multiple options with a focus on impact on quality, time, and cost. Their influence and engagement skills allow them to work with a highly motivated team and manage stakeholders at all levels of the company. This role is based in Waltham, MA without the possibility of being a remote role. Primary Responsibilities Include: Lead the operations of one or more high performing cross-functional teams, with focus on both the “what”, such as priorities, goal achievement, and resources, and the “how” of maintaining a challenging, collaborative, and sustainable team environment Partner with the PTL to identify short, medium, and long-term team priorities and propose path to address Drive execution of the established and aligned Program vision and strategy for bringing a life-changing medicine to patients in need Facilitate creation & maintenance of core program strategy documents including Target Product Profile (TPP), Clinical Development Plan, Regulatory Strategy, and Supply Strategy in collaboration with cross-functional representatives Ensure that non-clinical, clinical, regulatory, and commercialization strategies and plans are aligned with the TPP and the overall Program Strategy Inspire development of an efficient plan to achieve development and commercialization strategy, optimizing for quality, speed and cost Ensure that program decisions are made in a timely, clear and efficient manner through interactions with the PTL, Program Team members, governance forums and other key stakeholders Accountable for creation and maintenance of detailed cross-functional plans and effective visual summaries thereof to instill awareness, build accountability and facilitate achievement Maintain clear and open communication with Program Team, Dyne Senior Leadership, and other stakeholders regarding program status, priorities, risks and needs, and facilitate appropriate strategic decision-making Partner with Head of Program Management to evolve Program Management discipline to meet needs of a growing organization that intends to launch a portfolio of disease products Keep abreast of emerging developments regarding research and development in the fields of muscle diseases and oligonucleotide drug discovery and development Foster a culture of collaboration, innovation, discovery, and cutting-edge research culture focused on scientific excellence, open communication, and continual improvement Education and Skills Requirements: Proven and respected team member with: Bachelor’s degree in science or related field; Advanced degree in a scientific discipline or MBA preferred 15 years of relevant experience in biotech/pharmaceutical industry in positions of increasing responsibility in drug development Experience with late-stage clinical development and commercial stage programs required Experience with neuromuscular diseases a plus Exceptional communication skills (verbal, written, presentation) and ability to communicate with across a broad group of stakeholders and teams Proficient with Microsoft Office 365 applications, Smartsheet and other PM management workspace collaboration tools Expert at cross-functional teamwork and influencing without direct authority Demonstrated experience in working with highly effective teams and guiding teams and organizations in making complex and high-stakes data-driven decisions Passionate about developing and commercializing life-transforming therapies for patients with severe and life-threatening diseases Adept at operating in cross-functional matrix teams, developing effective relationships based on mutual trust and effective communication and thrives in a fast-paced, patient-focused environment Proven ability to establish and maintain credible and trust-based relationships Outstanding sense of urgency and ability to help pace the team’s work in highly competitive environment Orientation towards collective achievement and team credit, combined with individual sense of responsibility and accountability for teamwork and product Comfort with ambiguity and ability to provide steadiness and consistency in environment of shifting priorities Ability to lead without authority through complex and ambitious projects in a cross-functional team environment and high-pressure circumstances Comfortable in a results-driven, highly accountable environment where you can make a clear impact Team player who listens effectively and invites response and discussion A collaborator who communicates in an open, clear, complete, timely and consistent manner MA Pay Range $233,000 - $285,000 USD The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Keywords: Dyne Therapeutics, North Attleborough , Senior Director, Program Management, Manufacturing , Waltham, Massachusetts